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Zach Cregger Wants 'Mad Men' Actress to play Lady Dimitrescu

According to Zach Cregger, Christina Hendricks would be excellent in the role.

Omelete
2 min read
September 17, 2026, at 10:36 AM

In an interview with Pedestrian.TV, director Zach Cregger revealed which actress he would cast to play Lady Dimitrescu in a hypothetical live-action Resident Evil film. The choice was Christina Hendricks, known for her role as Joan Holloway in Mad Men.

"Christina Hendricks. That seems right to me. What do you think?", he said. The iconic character from Resident Evil Village, released in 2021, does not appear in Cregger's latest film, which is betting on an original story. Still, the director, a self-proclaimed fan of the franchise, seems to know who he would call if he had the chance.

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Lady Dimitrescu won over fans with her gigantic stature and femme fatale look. Her popularity was so great that Capcom even distributed life-size cardboard cutouts of the character in video game stores. Even without returning to the series, she remains a favorite, and her costume can be unlocked in Resident Evil Requiem for those who purchased the Deluxe Edition.

Everything you need to know about the new Resident Evil

Starring Austin Abrams, the film follows a medical deliveryman who finds himself in the middle of an outbreak of infected creatures.

The cast also includes Paul Walter Hauser (Fantastic Four: First Steps), Kali Reis (True Detective), Zach Cherry (Severance), and Johnno Wilson (I Love That For You).

The new version of Resident Evil arrives in theaters on September 17th, with Shay Hatten (Ballerina) handling the script and Zach Cregger (Weapons) directing.

When the reboot was announced, four studios were vying for the film, with Warner and Netflix emerging as some of the leading contenders. However, the project will remain with Sony and is being overseen by Columbia Pictures.

Interestingly, this is the second reboot of the franchise, which had Resident Evil: Welcome to Raccoon City in 2021, as well as a Netflix series that left a bitter taste for fans of the Capcom game series.

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